DOI:
https://doi.org/10.14483/22484728.18431Publicado:
2019-12-06Número:
Vol. 2 Núm. 2 (2019): Edición especialSección:
Visión InvestigadoraKinetic model of the dispersive interaction between a particle with an erythrocyte
Modelo cinético de la interacción dispersiva entre una partícula con un eritrocito
Palabras clave:
Nanoparticle delivery, Particle-erythrocyte interaction, Dispersion, Elastic collision (en).Palabras clave:
Nanoparticle delivery, Interacción partícula-eritrocito, Dispersión, Colisión elástica (es).Descargas
Resumen (en)
A kinetic model of interaction between nanomicroparticle (NMP) and an erythrocyte (RC) was developed considering an elastic type collision, taking into account that the main dispersion center in the delivery of drugs through the bloodstream are the RC. For the analysis of the model, three cases were considered where the position and speed of the MPN were varied. In case 1, the initial position of the MPN was varied with respect to the x axis; In case 2, there was a variation of the position with respect to the y axis, and finally, the speed with respect to the x axis was varied. This study allowed calculating the angle of dispersion (α) based on the impact parameter (s) with respect to the axis of symmetry of the RC. It was verified that in frontal collisions with s values close to the center of the axis of symmetry, the NMP presents the same incident trajectory, with a null angle of dispersion. In an oblique collision, the dispersion is greater and dependent on the initial position and the speed in its Cartesian components, thus a dependency with respect to the initial position is identified, as well as the direction of movement given by the speed components, which it is reflected in the variation of the angle of dispersion.
Resumen (es)
Se desarrolló un modelo cinético de interacción entre nanomicropartícula (NMP) y un eritrocito (RC) considerando una colisión de tipo elástica, teniendo en cuenta que el principal centro de dispersión en la entrega de medicamentos por el torrente sanguíneo son los RC. Para el análisis del modelo se consideró tres casos donde se varió la posición y velocidad de la NMP. En el caso 1 se varió la posición inicial de la NMP con respecto al eje x; en el caso 2 hubo variación de la posición respecto al eje y, por último, se varió la velocidad con respecto al eje x. Este estudio permitió calcular el ángulo de dispersión (α) en función del parámetro de impacto (s) respecto al eje de simetría del RC. Se verificó que en colisiones frontales con valores de s cercanos al centro del eje de simetría, la NMP presenta la misma trayectoria incidente, con un ángulo de dispersión nulo. En una colisión oblicua la dispersión es mayor y dependiente de la posición inicial y la velocidad en sus componentes cartesianos, de esta forma se identifica una dependencia respecto a la posición inicial, así como el sentido del movimiento dado por las componentes de la velocidad, que se ve reflejado en la variación del ángulo de dispersión.
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